| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Grafton | 40 | Pendleton County () | 14 | 264 | |
| 2021-09-03 | A | L | Grafton | 35 | East Fairmont () | 37 | 239 | |
| 2021-09-10 | H | L | Grafton | 7 | Lincoln () | 27 | 265 | |
| 2021-09-17 | A | W | Grafton | 28 | South Harrison () | 20 | 266 | |
| 2021-09-24 | H | W | Grafton | 41 | Liberty-Harrison () | 34 | 267 | |
| 2021-10-01 | A | W | Grafton | 46 | Elkins () | 13 | 248 | |
| 2021-10-08 | H | W | Grafton | 48 | Richwood () | 6 | 268 | |
| 2021-10-22 | H | W | Grafton | 47 | Buckhannon-Upshur () | 14 | 45 | |
| 2021-10-28 | H | W | Grafton | 1 | Philip Barbour () | 0 | 1258 | |
| 2021-11-05 | H | W | Grafton | 48 | Lewis County () | 6 | 270 | |
| 2021-11-12 | A | L | Grafton | 14 | North Marion () | 64 | 6-11 1st RD | 1279 |