| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Clay County | 22 | Midland Trail () | 21 | 230 | |
| 2021-09-10 | H | L | Clay County | 0 | Roane County () | 1 | 1197 | |
| 2021-09-17 | A | W | Clay County | 18 | Sissonville () | 7 | 233 | |
| 2021-09-24 | H | L | Clay County | 2 | Liberty-Raleigh () | 14 | 234 | |
| 2021-10-01 | H | W | Clay County | 20 | Philip Barbour () | 12 | 231 | |
| 2021-10-08 | H | L | Clay County | 0 | Nitro () | 1 | 236 | |
| 2021-10-15 | A | L | Clay County | 16 | Lincoln County () | 52 | 130 | |
| 2021-10-22 | A | W | Clay County | 20 | River View () | 6 | 237 | |
| 2021-10-26 | H | W | Clay County | 46 | Tug Valley () | 6 | 1234 | |
| 2021-11-05 | H | W | Clay County | 61 | Braxton County () | 27 | 219 |