| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-26 | A | L | PikeView | 7 | Summers County () | 36 | 349 | |
| 2021-09-03 | H | L | PikeView | 28 | Van () | 52 | 350 | |
| 2021-10-01 | H | L | PikeView | 14 | James Monroe () | 62 | 353 | |
| 2021-10-04 | H | L | PikeView | 6 | Westside () | 40 | 351 | |
| 2021-10-11 | A | L | PikeView | 0 | Bluefield () | 66 | 207 | |
| 2021-10-22 | H | W | PikeView | 28 | Wyoming East () | 12 | 354 | |
| 2021-10-29 | H | W | PikeView | 36 | River View () | 26 | 355 | |
| 2021-11-01 | A | L | PikeView | 0 | Liberty-Raleigh () | 1 | 1261 | |
| 2021-11-02 | H | L | PikeView | 26 | Shady Spring () | 40 | 352 | |
| 2021-11-05 | A | L | PikeView | 14 | Nicholas County () | 54 | 335 |