| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Musselman | 56 | Spring Mills () | 23 | 157 | |
| 2021-09-03 | H | L | Musselman | 14 | Martinsburg () | 56 | 133 | |
| 2021-09-10 | H | L | Musselman | 12 | Jefferson () | 47 | 110 | |
| 2021-09-17 | H | L | Musselman | 43 | Sherando (VA) () | 49 | 145 | |
| 2021-10-01 | A | L | Musselman | 14 | Morgantown () | 34 | 141 | |
| 2021-10-08 | A | W | Musselman | 35 | Hedgesville () | 0 | 94 | |
| 2021-10-15 | H | W | Musselman | 25 | Wheeling Park () | 17 | 158 | |
| 2021-10-22 | A | L | Musselman | 28 | Washington () | 29 | 159 | |
| 2021-10-29 | A | L | Musselman | 27 | Bridgeport () | 63 | 27 | |
| 2021-11-05 | H | L | Musselman | 52 | Parkersburg () | 56 | 10 |