| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Preston | 0 | Hampshire () | 21 | 79 | |
| 2021-09-10 | H | L | Preston | 7 | John Marshall () | 48 | 119 | |
| 2021-09-17 | H | L | Preston | 0 | Robert C. Byrd () | 1 | 1180 | |
| 2021-09-24 | A | L | Preston | 0 | East Fairmont () | 1 | 169 | |
| 2021-09-30 | A | L | Preston | 12 | North Marion () | 31 | 167 | |
| 2021-10-08 | A | L | Preston | 0 | Bridgeport () | 72 | 25 | |
| 2021-10-15 | H | L | Preston | 13 | Washington () | 14 | 170 | |
| 2021-10-22 | H | L | Preston | 8 | University () | 56 | 171 | |
| 2021-10-29 | A | W | Preston | 30 | Buckhannon-Upshur () | 14 | 46 | |
| 2021-11-05 | A | L | Preston | 7 | Brooke () | 14 | 38 |