| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | H | L | Capital | 28 | Parkersburg South () | 29 | 11 | |
| 2021-09-04 | H | L | Capital | 21 | South Charleston () | 42 | 56 | |
| 2021-09-10 | A | L | Capital | 20 | Parkersburg () | 28 | 3 | |
| 2021-09-17 | A | W | Capital | 42 | Riverside () | 22 | 57 | |
| 2021-09-24 | H | L | Capital | 7 | Huntington () | 30 | 58 | |
| 2021-10-08 | H | L | Capital | 0 | Cabell Midland () | 14 | 53 | |
| 2021-10-15 | H | L | Capital | 13 | Spring Valley () | 49 | 59 | |
| 2021-10-22 | A | L | Capital | 6 | Hurricane () | 54 | 60 | |
| 2021-10-29 | H | L | Capital | 19 | St. Albans () | 27 | 61 | |
| 2021-11-05 | A | L | Capital | 0 | George Washington () | 41 | 62 |