| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | South Charleston | 37 | Morgantown () | 28 | 139 | |
| 2021-09-04 | A | W | South Charleston | 42 | Capital () | 21 | 56 | |
| 2021-09-10 | H | W | South Charleston | 55 | St. Albans () | 0 | 182 | |
| 2021-09-24 | A | L | South Charleston | 8 | Spring Valley () | 53 | 183 | |
| 2021-10-01 | H | W | South Charleston | 14 | George Washington () | 13 | 67 | |
| 2021-10-09 | H | W | South Charleston | 38 | Parkersburg () | 21 | 7 | |
| 2021-10-15 | A | L | South Charleston | 14 | Riverside () | 22 | 181 | |
| 2021-10-22 | H | L | South Charleston | 21 | Huntington () | 52 | 101 | |
| 2021-10-29 | A | L | South Charleston | 27 | Hurricane () | 28 | 106 | |
| 2021-11-05 | H | L | South Charleston | 21 | Woodrow Wilson () | 42 | 184 | |
| 2021-11-12 | A | L | South Charleston | 12 | Cabell Midland () | 49 | 5-12 1st RD | 1283 |