| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | George Washington | Huntington () | Quarterfinals OT1289 | ||||
| 2021-08-26 | A | W | George Washington | 49 | St. Albans () | 0 | 63 | |
| 2021-09-03 | A | W | George Washington | 35 | Ashland (KY) () | 21 | 64 | |
| 2021-09-10 | H | W | George Washington | 35 | Hurricane () | 14 | 65 | |
| 2021-09-17 | H | L | George Washington | 14 | Huntington () | 30 | 66 | |
| 2021-10-01 | A | L | George Washington | 13 | South Charleston () | 14 | 67 | |
| 2021-10-08 | H | W | George Washington | 49 | Riverside () | 0 | 68 | |
| 2021-10-15 | A | L | George Washington | 7 | Cabell Midland () | 35 | 54 | |
| 2021-10-22 | H | W | George Washington | 48 | Woodrow Wilson () | 35 | 69 | |
| 2021-10-29 | A | W | George Washington | 28 | Parkersburg () | 24 | 9 | |
| 2021-11-05 | H | W | George Washington | 41 | Capital () | 0 | 62 | |
| 2021-11-12 | A | W | George Washington | 21 | Greenbrier East () | 7 | 8-9 1st RD | 1281 |
| 2021-11-19 | A | L | George Washington | 13 | Huntington () | 29 | Quarterfinals | 1294 |