| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Greenbrier East | 32 | Pt. Pleasant (8) | 22 | Hx 70 | |
| 2021-09-03 | A | W | Greenbrier East | 28 | Woodrow Wilson (4) | 14 | Hx 71 | |
| 2021-09-10 | H | L | Greenbrier East | 16 | Robert C. Byrd (7) | 31 | Hx 72 | |
| 2021-09-17 | H | W | Greenbrier East | 56 | Buckhannon-Upshur (0) | 14 | Hx 41 | |
| 2021-10-01 | A | W | Greenbrier East | 55 | Mingo Central (2) | 12 | Hx 73 | |
| 2021-10-08 | H | L | Greenbrier East | 3 | Oak Hill (2) | 23 | Hx 74 | |
| 2021-10-15 | A | W | Greenbrier East | 42 | Ripley (1) | 7 | Hx 75 | |
| 2021-10-22 | A | W | Greenbrier East | 56 | Hampshire (2) | 6 | Hx 76 | |
| 2021-10-29 | H | W | Greenbrier East | 23 | Princeton (4) | 17 | Hx 77 | |
| 2021-11-05 | H | W | Greenbrier East | 61 | Lincoln County (2) | 22 | Hx 78 | |
| 2021-11-12 | H | L | Greenbrier East | 7 | George Washington (8) | 21 | 8-9 1st RD | Hx 1281 |