| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Valley-Wetzel | 0 | Tygarts Valley () | 49 | 628 | |
| 2021-09-03 | A | L | Valley-Wetzel | 6 | Calhoun County () | 28 | 471 | |
| 2021-09-10 | A | L | Valley-Wetzel | 8 | Clay-Battelle () | 49 | 487 | |
| 2021-09-17 | H | L | Valley-Wetzel | 12 | Frontier (OH) () | 54 | 448 | |
| 2021-09-24 | A | W | Valley-Wetzel | 38 | Beallsville (OH) () | 16 | 449 | |
| 2021-10-01 | H | L | Valley-Wetzel | 6 | South Harrison () | 26 | 619 | |
| 2021-10-08 | H | L | Valley-Wetzel | 8 | Cameron () | 62 | 483 | |
| 2021-10-29 | H | L | Valley-Wetzel | 12 | Tyler Consolidated () | 55 | 629 | |
| 2021-11-02 | H | W | Valley-Wetzel | 52 | Hundred () | 22 | 1237 | |
| 2021-11-05 | A | W | Valley-Wetzel | 46 | Paden City () | 20 | 590 |