| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | St. Marys | 0 | Roane County () | 6 | 377 | |
| 2021-09-03 | A | W | St. Marys | 30 | Ravenswood () | 14 | 601 | |
| 2021-09-17 | A | L | St. Marys | 7 | Ritchie County () | 36 | 612 | |
| 2021-09-24 | A | W | St. Marys | 48 | Calhoun County () | 0 | 474 | |
| 2021-10-01 | H | L | St. Marys | 13 | Williamstown () | 17 | 561 | |
| 2021-10-08 | A | W | St. Marys | 22 | Wirt County () | 6 | 565 | |
| 2021-10-15 | H | W | St. Marys | 34 | Magnolia () | 7 | 543 | |
| 2021-10-22 | H | W | St. Marys | 41 | South Harrison () | 6 | 620 | |
| 2021-10-29 | A | L | St. Marys | 6 | East Hardy () | 36 | 504 | |
| 2021-11-05 | H | W | St. Marys | 36 | Tyler Consolidated () | 16 | 622 |