| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | W | Keyser | 45 | Berkeley Springs () | 14 | 196 | |
| 2021-09-17 | H | W | Keyser | 35 | Robert C. Byrd () | 13 | 289 | |
| 2021-09-24 | A | W | Keyser | 50 | Hampshire () | 14 | 83 | |
| 2021-10-01 | A | L | Keyser | 19 | Northern Garrett County (MD) () | 34 | 291 | |
| 2021-10-08 | H | L | Keyser | 33 | Pt. Pleasant () | 35 | 292 | |
| 2021-10-15 | A | L | Keyser | 14 | Allegany (MD) () | 31 | 293 | |
| 2021-10-22 | H | W | Keyser | 16 | Moorefield () | 14 | 295 | |
| 2021-10-25 | H | W | Keyser | 1 | Oak Glen () | 0 | 1252 | |
| 2021-10-29 | A | L | Keyser | 8 | Mt. Ridge (MD) () | 33 | 294 | |
| 2021-11-05 | H | L | Keyser | 35 | Frankfort () | 41 | 263 |