| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Frankfort | 19 | Moorefield () | 0 | 259 | |
| 2021-09-03 | H | W | Frankfort | 21 | Hampshire () | 8 | 80 | |
| 2021-09-10 | H | W | Frankfort | 21 | Washington () | 0 | 192 | |
| 2021-09-17 | H | W | Frankfort | 67 | Berkeley Springs () | 26 | 198 | |
| 2021-09-24 | A | L | Frankfort | 6 | Northern Garrett County (MD) () | 28 | 260 | |
| 2021-10-01 | H | L | Frankfort | 13 | Mt. Ridge (MD) () | 48 | 261 | |
| 2021-10-08 | A | L | Frankfort | 20 | Spring Mills () | 21 | 186 | |
| 2021-10-22 | H | W | Frankfort | 53 | Elkins () | 0 | 251 | |
| 2021-10-29 | A | L | Frankfort | 19 | North Marion () | 42 | 262 | |
| 2021-11-05 | A | W | Frankfort | 41 | Keyser () | 35 | 263 | |
| 2021-11-12 | A | W | Frankfort | 21 | Lincoln () | 17 | 4-13 1st RD | 1274 |
| 2021-11-20 | A | L | Frankfort | 49 | Poca () | 56 | Quarterfinals | 1299 |