| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Roane County | 6 | St. Marys () | 0 | 377 | |
| 2021-09-03 | H | L | Roane County | 28 | Lincoln County () | 30 | 125 | |
| 2021-09-10 | A | W | Roane County | 1 | Clay County () | 0 | 1197 | |
| 2021-09-20 | H | W | Roane County | 55 | Lewis County () | 0 | 296 | |
| 2021-09-25 | A | W | Roane County | 22 | Buffalo () | 3 | 378 | |
| 2021-10-01 | A | W | Roane County | 44 | Ripley () | 7 | 174 | |
| 2021-10-15 | H | W | Roane County | 57 | Braxton County () | 6 | 216 | |
| 2021-10-22 | A | L | Roane County | 16 | Doddridge County () | 44 | 379 | |
| 2021-10-29 | A | W | Roane County | 28 | Ravenswood () | 7 | 380 | |
| 2021-11-05 | H | W | Roane County | 58 | Sissonville () | 40 | 381 | |
| 2021-11-12 | A | W | Roane County | 18 | Nicholas County () | 15 | 7-10 1st RD | 1277 |
| 2021-11-19 | A | L | Roane County | 8 | Independence () | 22 | Quarterfinals | 1300 |