| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | L | Bluefield | 36 | Princeton () | 39 | 172 | |
| 2021-10-08 | H | L | Bluefield | 6 | Graham (VA) () | 31 | 204 | |
| 2021-10-11 | H | W | Bluefield | 66 | PikeView () | 0 | 207 | |
| 2021-10-15 | A | W | Bluefield | 57 | Tazewell (VA) () | 14 | 208 | |
| 2021-10-22 | A | W | Bluefield | 41 | Oak Hill () | 21 | 164 | |
| 2021-10-27 | A | L | Bluefield | 0 | Woodrow Wilson () | 1 | 1256 | |
| 2021-10-29 | A | W | Bluefield | 21 | Ridgeview (VA) () | 19 | 209 | |
| 2021-11-05 | H | W | Bluefield | 55 | Mingo Central () | 6 | 210 | |
| 2021-11-13 | A | W | Bluefield | 44 | Pt. Pleasant () | 20 | 3-14 1st RD | 1278 |
| 2021-11-19 | A | W | Bluefield | 35 | North Marion () | 21 | Quarterfinals | 1301 |
| 2021-11-26 | A | L | Bluefield | 20 | Independence () | 34 | Semifinals | 1310 |