| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Nicholas County | 27 | Oak Hill () | 25 | 160 | |
| 2021-09-03 | A | W | Nicholas County | 38 | Shady Spring () | 14 | 330 | |
| 2021-09-16 | H | L | Nicholas County | 13 | Lincoln () | 21 | 313 | |
| 2021-09-24 | H | W | Nicholas County | 53 | Wyoming East () | 8 | 331 | |
| 2021-10-01 | A | W | Nicholas County | 47 | Midland Trail () | 22 | 332 | |
| 2021-10-08 | A | W | Nicholas County | 57 | Braxton County () | 13 | 215 | |
| 2021-10-15 | H | W | Nicholas County | 1 | Westside () | 0 | 1233 | |
| 2021-10-22 | H | L | Nicholas County | 21 | Independence () | 57 | 287 | |
| 2021-10-29 | H | W | Nicholas County | 25 | James Monroe () | 7 | 334 | |
| 2021-11-05 | H | W | Nicholas County | 54 | PikeView () | 14 | 335 | |
| 2021-11-12 | H | L | Nicholas County | 15 | Roane County () | 18 | 7-10 1st RD | 1277 |