| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Greenbrier East | 32 | Pt. Pleasant () | 22 | 70 | |
| 2021-09-03 | A | W | Greenbrier East | 28 | Woodrow Wilson () | 14 | 71 | |
| 2021-09-10 | H | L | Greenbrier East | 16 | Robert C. Byrd () | 31 | 72 | |
| 2021-09-17 | H | W | Greenbrier East | 56 | Buckhannon-Upshur () | 14 | 41 | |
| 2021-10-01 | A | W | Greenbrier East | 55 | Mingo Central () | 12 | 73 | |
| 2021-10-08 | H | L | Greenbrier East | 3 | Oak Hill () | 23 | 74 | |
| 2021-10-15 | A | W | Greenbrier East | 42 | Ripley () | 7 | 75 | |
| 2021-10-22 | A | W | Greenbrier East | 56 | Hampshire () | 6 | 76 | |
| 2021-10-29 | H | W | Greenbrier East | 23 | Princeton () | 17 | 77 | |
| 2021-11-05 | H | W | Greenbrier East | 61 | Lincoln County () | 22 | 78 | |
| 2021-11-12 | H | L | Greenbrier East | 7 | George Washington () | 21 | 8-9 1st RD | 1281 |