| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Parkersburg | 7 | Huntington () | 47 | 1 | |
| 2021-09-03 | H | L | Parkersburg | 10 | Spring Valley () | 34 | 2 | |
| 2021-09-10 | H | W | Parkersburg | 28 | Capital () | 20 | 3 | |
| 2021-09-17 | H | W | Parkersburg | 28 | Parkersburg South () | 19 | 4 | |
| 2021-09-24 | A | L | Parkersburg | 6 | Cabell Midland () | 45 | 5 | |
| 2021-10-01 | H | L | Parkersburg | 30 | Hurricane () | 42 | 6 | |
| 2021-10-09 | A | L | Parkersburg | 21 | South Charleston () | 38 | 7 | |
| 2021-10-22 | A | W | Parkersburg | 31 | Riverside () | 7 | 8 | |
| 2021-10-29 | H | L | Parkersburg | 24 | George Washington () | 28 | 9 | |
| 2021-11-05 | A | W | Parkersburg | 56 | Musselman () | 52 | 10 |