| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-26 | H | L | St. Albans | 0 | George Washington () | 49 | 63 | |
| 2021-09-03 | H | W | St. Albans | 6 | Nitro () | 3 | 189 | |
| 2021-09-10 | A | L | St. Albans | 0 | South Charleston () | 55 | 182 | |
| 2021-09-17 | H | L | St. Albans | 0 | Spring Valley () | 54 | 187 | |
| 2021-09-24 | A | L | St. Albans | 8 | Hurricane () | 54 | 104 | |
| 2021-10-01 | H | L | St. Albans | 7 | Riverside () | 22 | 180 | |
| 2021-10-08 | A | W | St. Albans | 26 | Ripley () | 14 | 175 | |
| 2021-10-15 | A | L | St. Albans | 7 | Huntington () | 56 | 100 | |
| 2021-10-29 | A | W | St. Albans | 27 | Capital () | 19 | 61 | |
| 2021-11-05 | H | L | St. Albans | 0 | Cabell Midland () | 55 | 55 |