| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | Cabell Midland | University () | Quarterfinals OT1290 | ||||
| 2021-08-27 | A | W | Cabell Midland | 28 | Spring Valley () | 19 | 48 | |
| 2021-09-03 | H | W | Cabell Midland | 56 | Riverside () | 0 | 49 | |
| 2021-09-10 | A | L | Cabell Midland | 17 | Huntington () | 21 | 50 | |
| 2021-09-17 | H | W | Cabell Midland | 44 | Hurricane () | 25 | 51 | |
| 2021-09-24 | H | W | Cabell Midland | 45 | Parkersburg () | 6 | 5 | |
| 2021-10-01 | A | W | Cabell Midland | 56 | Oak Hill () | 16 | 52 | |
| 2021-10-08 | A | W | Cabell Midland | 14 | Capital () | 0 | 53 | |
| 2021-10-15 | H | W | Cabell Midland | 35 | George Washington () | 7 | 54 | |
| 2021-10-22 | A | W | Cabell Midland | 70 | Parkersburg South () | 21 | 17 | |
| 2021-10-26 | A | Cabell Midland | Huntington () | Semifinals | 1306 | |||
| 2021-11-05 | A | W | Cabell Midland | 55 | St. Albans () | 0 | 55 | |
| 2021-11-12 | H | W | Cabell Midland | 49 | South Charleston () | 12 | 5-12 1st RD | 1283 |
| 2021-11-19 | A | W | Cabell Midland | 46 | University () | 21 | Quarterfinals | 1295 |
| 2021-11-26 | A | L | Cabell Midland | 15 | Huntington () | 37 | Semifinals | 1315 |