| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | W | Mingo Central | 43 | Wyoming East () | 12 | 324 | |
| 2021-09-10 | A | L | Mingo Central | 28 | Pt. Pleasant () | 66 | 325 | |
| 2021-09-17 | A | L | Mingo Central | 6 | Man () | 7 | 326 | |
| 2021-09-24 | H | L | Mingo Central | 13 | Poca () | 22 | 327 | |
| 2021-10-01 | H | L | Mingo Central | 12 | Greenbrier East () | 55 | 73 | |
| 2021-10-08 | H | W | Mingo Central | 65 | Tolsia () | 0 | 329 | |
| 2021-10-15 | A | W | Mingo Central | 45 | Shady Spring () | 12 | 328 | |
| 2021-10-22 | H | L | Mingo Central | 0 | Herbert Hoover () | 57 | 277 | |
| 2021-10-29 | A | L | Mingo Central | 20 | Chapmanville Regional () | 35 | 228 | |
| 2021-11-05 | A | L | Mingo Central | 6 | Bluefield () | 55 | 210 |