| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Hampshire | 21 | Preston () | 0 | 79 | |
| 2021-09-03 | A | L | Hampshire | 8 | Frankfort () | 21 | 80 | |
| 2021-09-10 | H | L | Hampshire | 7 | Spring Mills () | 51 | 81 | |
| 2021-09-17 | A | W | Hampshire | 69 | Park View-Sterling (VA) () | 37 | 82 | |
| 2021-09-24 | H | L | Hampshire | 14 | Keyser () | 50 | 83 | |
| 2021-10-08 | A | W | Hampshire | 35 | Petersburg () | 14 | 84 | |
| 2021-10-15 | A | L | Hampshire | 40 | Berkeley Springs () | 71 | 85 | |
| 2021-10-22 | H | L | Hampshire | 6 | Greenbrier East () | 56 | 76 | |
| 2021-10-29 | H | L | Hampshire | 0 | Washington () | 1 | 86 | |
| 2021-11-06 | H | L | Hampshire | 21 | Hedgesville () | 34 | 87 |