| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | A | W | Parkersburg South | 29 | Capital () | 28 | 11 | |
| 2021-09-03 | A | L | Parkersburg South | 33 | University () | 62 | 12 | |
| 2021-09-10 | H | W | Parkersburg South | 61 | Woodrow Wilson () | 13 | 13 | |
| 2021-09-17 | A | L | Parkersburg South | 19 | Parkersburg () | 28 | 4 | |
| 2021-09-24 | H | W | Parkersburg South | 28 | John Marshall () | 25 | 14 | |
| 2021-10-15 | A | L | Parkersburg South | 14 | Morgantown () | 21 | 16 | |
| 2021-10-22 | H | L | Parkersburg South | 21 | Cabell Midland () | 70 | 17 | |
| 2021-10-29 | A | W | Parkersburg South | 26 | Wheeling Park () | 24 | 18 | |
| 2021-11-01 | A | L | Parkersburg South | 0 | Bridgeport () | 1 | 1259 | |
| 2021-11-05 | H | W | Parkersburg South | 44 | Princeton () | 34 | 19 | |
| 2021-11-12 | A | L | Parkersburg South | 20 | Martinsburg () | 83 | 2-15 1st RD | 1284 |