| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Ripley | 7 | Brooke () | 28 | 29 | |
| 2021-09-03 | H | W | Ripley | 31 | Buckhannon-Upshur () | 13 | 39 | |
| 2021-09-10 | A | L | Ripley | 21 | Lincoln County () | 50 | 126 | |
| 2021-09-17 | A | L | Ripley | 14 | Marietta (OH) () | 34 | 148 | |
| 2021-09-24 | H | L | Ripley | 26 | Oak Hill () | 47 | 163 | |
| 2021-10-01 | H | L | Ripley | 7 | Roane County () | 44 | 174 | |
| 2021-10-08 | H | L | Ripley | 14 | St. Albans () | 26 | 175 | |
| 2021-10-15 | H | L | Ripley | 7 | Greenbrier East () | 42 | 75 | |
| 2021-10-22 | A | L | Ripley | 14 | Shady Spring () | 28 | 176 | |
| 2021-10-29 | A | L | Ripley | 0 | Pt. Pleasant () | 51 | 177 |