| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | A | L | Weir | 20 | Oak Glen (2) | 35 | Hx 342 | |
| 2021-09-03 | A | L | Weir | 0 | John Marshall (3) | 36 | Hx 118 | |
| 2021-09-10 | H | W | Weir | 19 | Indian Creek (OH) (0) | 13 | Hx 372 | |
| 2021-09-17 | A | L | Weir | 7 | Martins Ferry (OH) (1) | 38 | Hx 373 | |
| 2021-10-01 | A | L | Weir | 27 | Wheeling Central (9) | 54 | Hx 394 | |
| 2021-10-08 | H | L | Weir | 6 | Williamstown (11) | 31 | Hx 395 | |
| 2021-10-15 | A | L | Weir | 0 | Albert Gallatin (PA) (1) | 1 | Hx 1239 | |
| 2021-10-22 | H | L | Weir | 28 | East Liverpool (OH) (3) | 41 | Hx 376 | |
| 2021-10-29 | H | W | Weir | 29 | Brooke (3) | 6 | Hx 37 |