| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Williamstown | 12 | Waterford (OH) () | 18 | 2 OT458 | |
| 2021-09-04 | A | W | Williamstown | 34 | Warren Local (OH) () | 6 | 459 | |
| 2021-09-10 | H | W | Williamstown | 35 | Ravenswood () | 8 | 560 | |
| 2021-09-17 | A | W | Williamstown | 49 | Buffalo () | 6 | 463 | |
| 2021-10-01 | A | W | Williamstown | 17 | St. Marys () | 13 | 561 | |
| 2021-10-08 | A | W | Williamstown | 31 | Weir () | 6 | 395 | |
| 2021-10-15 | A | W | Williamstown | 42 | Tyler Consolidated () | 22 | 562 | |
| 2021-10-22 | H | L | Williamstown | 9 | Fort Frye (OH) () | 41 | 460 | |
| 2021-10-29 | H | W | Williamstown | 26 | Doddridge County () | 24 | 496 | |
| 2021-11-05 | H | W | Williamstown | 53 | Magnolia () | 6 | 545 | |
| 2021-11-13 | H | W | Williamstown | 48 | Greenbrier West () | 20 | 6-11 1st RD | 1271 |
| 2021-11-19 | A | W | Williamstown | 44 | East Hardy () | 24 | Quarterfinals | 1302 |
| 2021-11-26 | A | W | Williamstown | 43 | Doddridge County () | 0 | Semifinals | 1311 |
| 2021-12-04 | N | L | Williamstown | 21 | Ritchie County () | 42 | A CHAMPIONSHIP | 1320 |