| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | H | W | Oak Glen | 35 | Weir () | 20 | 342 | |
| 2021-09-17 | H | L | Oak Glen | 7 | Pt. Pleasant () | 42 | 344 | |
| 2021-10-01 | A | W | Oak Glen | 53 | Berkeley Springs () | 31 | 200 | |
| 2021-10-08 | A | L | Oak Glen | 14 | Brooke () | 21 | 34 | |
| 2021-10-15 | H | L | Oak Glen | 13 | East Liverpool (OH) () | 34 | 346 | |
| 2021-10-22 | H | L | Oak Glen | 6 | North Marion () | 60 | 341 | |
| 2021-10-25 | A | L | Oak Glen | 0 | Keyser () | 1 | 1252 | |
| 2021-10-29 | A | L | Oak Glen | 0 | John Marshall () | 42 | 122 | |
| 2021-11-04 | H | L | Oak Glen | 17 | Wheeling Central () | 55 | 1169 |