| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | A | L | Weir | 20 | Oak Glen () | 35 | 342 | |
| 2021-09-03 | A | L | Weir | 0 | John Marshall () | 36 | 118 | |
| 2021-09-10 | H | W | Weir | 19 | Indian Creek (OH) () | 13 | 372 | |
| 2021-09-17 | A | L | Weir | 7 | Martins Ferry (OH) () | 38 | 373 | |
| 2021-10-01 | A | L | Weir | 27 | Wheeling Central () | 54 | 394 | |
| 2021-10-08 | H | L | Weir | 6 | Williamstown () | 31 | 395 | |
| 2021-10-15 | A | L | Weir | 0 | Albert Gallatin (PA) () | 1 | 1239 | |
| 2021-10-22 | H | L | Weir | 28 | East Liverpool (OH) () | 41 | 376 | |
| 2021-10-29 | H | W | Weir | 29 | Brooke () | 6 | 37 |