| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Tyler Consolidated | 12 | Ritchie County () | 38 | 610 | |
| 2021-09-03 | H | L | Tyler Consolidated | 16 | Doddridge County () | 27 | 491 | |
| 2021-09-10 | A | W | Tyler Consolidated | 40 | South Harrison () | 0 | 618 | |
| 2021-09-20 | H | W | Tyler Consolidated | 46 | Calhoun County () | 14 | 473 | |
| 2021-09-24 | A | W | Tyler Consolidated | 38 | Wirt County () | 0 | 564 | |
| 2021-10-08 | H | W | Tyler Consolidated | 35 | Buffalo () | 0 | 465 | |
| 2021-10-15 | H | L | Tyler Consolidated | 22 | Williamstown () | 42 | 562 | |
| 2021-10-22 | H | W | Tyler Consolidated | 49 | Magnolia () | 7 | 544 | |
| 2021-10-29 | A | W | Tyler Consolidated | 55 | Valley-Wetzel () | 12 | 629 | |
| 2021-11-05 | A | L | Tyler Consolidated | 16 | St. Marys () | 36 | 622 |