| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Wyoming East | 28 | Westside () | 6 | 396 | |
| 2021-09-03 | H | L | Wyoming East | 12 | Mingo Central () | 43 | 324 | |
| 2021-09-17 | A | L | Wyoming East | 6 | Herbert Hoover () | 70 | 274 | |
| 2021-09-24 | A | L | Wyoming East | 8 | Nicholas County () | 53 | 331 | |
| 2021-10-08 | H | L | Wyoming East | 0 | Shady Spring () | 6 | 389 | |
| 2021-10-12 | A | L | Wyoming East | 13 | River View () | 36 | 400 | |
| 2021-10-15 | H | L | Wyoming East | 0 | Pt. Pleasant () | 1 | 361 | |
| 2021-10-22 | A | L | Wyoming East | 12 | PikeView () | 28 | 354 | |
| 2021-10-29 | A | L | Wyoming East | 8 | Independence () | 60 | 288 | |
| 2021-11-05 | H | L | Wyoming East | 6 | Liberty-Raleigh () | 54 | 311 |