| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Wheeling Park | 18 | St. Clairsville (OH) () | 14 | 153 | |
| 2021-09-03 | A | L | Wheeling Park | 16 | Steubenville (OH) () | 45 | 154 | |
| 2021-09-18 | H | L | Wheeling Park | 14 | University () | 35 | 190 | |
| 2021-10-08 | A | W | Wheeling Park | 41 | Morgantown () | 6 | 142 | |
| 2021-10-15 | A | L | Wheeling Park | 17 | Musselman () | 25 | 158 | |
| 2021-10-22 | H | W | Wheeling Park | 56 | Brooke () | 7 | 36 | |
| 2021-10-29 | H | L | Wheeling Park | 24 | Parkersburg South () | 26 | 18 | |
| 2021-11-05 | A | W | Wheeling Park | 35 | John Marshall () | 7 | 123 | |
| 2021-11-12 | A | L | Wheeling Park | 21 | Huntington () | 48 | 1-16 1st RD | 1280 |