| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | H | University | Cabell Midland () | Quarterfinals OT1290 | ||||
| 2021-08-27 | H | W | University | 55 | John Marshall () | 0 | 117 | |
| 2021-09-03 | H | W | University | 62 | Parkersburg South () | 33 | 12 | |
| 2021-09-10 | A | W | University | 52 | Brooke () | 20 | 31 | |
| 2021-09-18 | A | W | University | 35 | Wheeling Park () | 14 | 190 | |
| 2021-09-24 | H | W | University | 35 | Fairmont Sr. () | 6 | 191 | |
| 2021-10-08 | A | W | University | 36 | Albert Gallatin (PA) () | 14 | 151 | |
| 2021-10-15 | A | W | University | 63 | Buckhannon-Upshur () | 6 | 44 | |
| 2021-10-22 | A | W | University | 56 | Preston () | 8 | 171 | |
| 2021-10-29 | H | W | University | 49 | Morgantown () | 14 | 143 | |
| 2021-11-05 | H | W | University | 63 | Oak Hill () | 21 | 166 | |
| 2021-11-12 | H | W | University | 52 | Woodrow Wilson () | 10 | 4-13 1st RD | 1282 |
| 2021-11-19 | H | L | University | 21 | Cabell Midland () | 46 | Quarterfinals | 1295 |