| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Morgantown | 28 | South Charleston () | 37 | 139 | |
| 2021-09-03 | A | L | Morgantown | 20 | Bridgeport () | 31 | 21 | |
| 2021-09-17 | H | W | Morgantown | 62 | Hedgesville () | 20 | 91 | |
| 2021-09-24 | A | L | Morgantown | 27 | Woodrow Wilson () | 28 | 1 OT140 | |
| 2021-10-01 | H | W | Morgantown | 34 | Musselman () | 14 | 141 | |
| 2021-10-08 | H | L | Morgantown | 6 | Wheeling Park () | 41 | 142 | |
| 2021-10-15 | H | W | Morgantown | 21 | Parkersburg South () | 14 | 16 | |
| 2021-10-22 | A | W | Morgantown | 33 | John Marshall () | 7 | 121 | |
| 2021-10-29 | A | L | Morgantown | 14 | University () | 49 | 143 | |
| 2021-11-05 | A | W | Morgantown | 49 | Spring Mills () | 13 | 144 | |
| 2021-11-12 | A | L | Morgantown | 7 | Bridgeport () | 34 | 3-14 1st RD | 1286 |