| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | Wheeling Central | Ritchie County () | 1313 | ||||
| 2021-08-27 | H | W | Wheeling Central | 36 | Ambridge (PA) () | 14 | 451 | |
| 2021-09-04 | A | W | Wheeling Central | 52 | Tuscarawas Cent. Cath. (OH) () | 18 | 452 | |
| 2021-09-11 | A | L | Wheeling Central | 7 | Bellaire (OH) () | 14 | 453 | |
| 2021-09-17 | H | L | Wheeling Central | 21 | Shadyside (OH) () | 33 | 454 | |
| 2021-09-24 | H | W | Wheeling Central | 49 | Man () | 21 | 547 | |
| 2021-10-01 | H | W | Wheeling Central | 54 | Weir () | 27 | 394 | |
| 2021-10-08 | A | W | Wheeling Central | 47 | Martins Ferry (OH) () | 6 | 455 | |
| 2021-10-14 | A | L | Wheeling Central | 0 | St. Clairsville (OH) () | 35 | 456 | |
| 2021-10-22 | H | W | Wheeling Central | 21 | Beaver Local (OH) () | 7 | 457 | |
| 2021-11-04 | A | W | Wheeling Central | 55 | Oak Glen () | 17 | 1169 | |
| 2021-11-13 | H | W | Wheeling Central | 35 | Moorefield () | 7 | 8-9 1st RD | 1265 |
| 2021-11-20 | H | W | Wheeling Central | 55 | Gilmer County () | 0 | Quarterfinals | 1303 |
| 2021-11-27 | A | L | Wheeling Central | 16 | Ritchie County () | 20 | Semifinals | 1314 |