| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Pt. Pleasant | 22 | Greenbrier East () | 32 | 70 | |
| 2021-09-03 | H | W | Pt. Pleasant | 26 | Gallia Academy (OH) () | 22 | 360 | |
| 2021-09-10 | H | W | Pt. Pleasant | 66 | Mingo Central () | 28 | 325 | |
| 2021-09-17 | A | W | Pt. Pleasant | 42 | Oak Glen () | 7 | 344 | |
| 2021-09-24 | A | W | Pt. Pleasant | 48 | Lincoln County () | 20 | 128 | |
| 2021-10-08 | A | W | Pt. Pleasant | 35 | Keyser () | 33 | 292 | |
| 2021-10-15 | A | W | Pt. Pleasant | 1 | Wyoming East () | 0 | 361 | |
| 2021-10-22 | H | W | Pt. Pleasant | 41 | Man () | 14 | 362 | |
| 2021-10-29 | H | W | Pt. Pleasant | 51 | Ripley () | 0 | 177 | |
| 2021-11-05 | A | W | Pt. Pleasant | 17 | Winfield () | 14 | 363 | |
| 2021-11-13 | H | L | Pt. Pleasant | 20 | Bluefield () | 44 | 3-14 1st RD | 1278 |