| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Brooke | 28 | Ripley () | 7 | 29 | |
| 2021-09-02 | A | W | Brooke | 28 | Indian Creek (OH) () | 13 | 30 | |
| 2021-09-10 | H | L | Brooke | 20 | University () | 52 | 31 | |
| 2021-10-01 | H | W | Brooke | 30 | Marietta (OH) () | 21 | 33 | |
| 2021-10-08 | H | W | Brooke | 21 | Oak Glen () | 14 | 34 | |
| 2021-10-14 | A | L | Brooke | 6 | John Marshall () | 41 | 35 | |
| 2021-10-22 | A | L | Brooke | 7 | Wheeling Park () | 56 | 36 | |
| 2021-10-29 | A | L | Brooke | 6 | Weir () | 29 | 37 | |
| 2021-11-05 | H | W | Brooke | 14 | Preston () | 7 | 38 |