| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | John Marshall | 0 | University () | 55 | 117 | |
| 2021-09-03 | H | W | John Marshall | 36 | Weir () | 0 | 118 | |
| 2021-09-10 | A | W | John Marshall | 48 | Preston () | 7 | 119 | |
| 2021-09-17 | H | W | John Marshall | 34 | Trimble (OH) () | 33 | 120 | |
| 2021-09-24 | A | L | John Marshall | 25 | Parkersburg South () | 28 | 14 | |
| 2021-10-01 | A | W | John Marshall | 33 | Buckhannon-Upshur () | 14 | 42 | |
| 2021-10-14 | H | W | John Marshall | 41 | Brooke () | 6 | 35 | |
| 2021-10-22 | H | L | John Marshall | 7 | Morgantown () | 33 | 121 | |
| 2021-10-29 | H | W | John Marshall | 42 | Oak Glen () | 0 | 122 | |
| 2021-11-05 | H | L | John Marshall | 7 | Wheeling Park () | 35 | 123 |